Lifehacker reader brandedman organised his home screen around 16 shortcuts -- four per screen -- along with a clean and unified look to tie it all together.
This nice clean interface puts my most-used apps at my fingertips. I use ADWLauncher EX and the Metrostation icon pack for the icons. Using Minimalistic Text, I created the text label that goes next to each shortcut, and tapping on it takes you to the same app that the icon would.
The home screen works really well with the "notification bar hidden" option of ADW and uses ADWNotifier to place notifications over the icon for specific apps like Facebook, Email or Messaging.
For the weather and battery icons, I use Simi Clock to create the graphic and Minimalistic Text to display the information beside it.