One-way car rentals are notoriously more expensive than when you pick-up and drop-off at the same location. It turns out that if you mess around with different locations for picking up and dropping off, you might be able to save a little cash.
The natural inclination is to just set your pick-up and drop-off locations for a rental car as the nearest airports, but while I was researching prices for a trip that I'm taking, I found that's rarely the cheapest option. Just like booking a regular round-trip car, it's best to forgo the airport pick-up and experiment with other locations. In my case, playing around with these options ended up saving me a good amount of money, which is well worth the loss of convenience and the extra taxi ride. It's also worth noting that it wasn't always cheaper to skip the airport locations, so keep them in your search.
You don't have to go through and search through every single location at every single rental car company looking for a deal, some sites, like Kayak let you specify "non-airport" agencies in your search, so you'll see the prices for various locations all in one place. Sometimes the difference is a few dollars. Other times it's much more.