If you fancy an alcoholic drink or two when you're on a plane, keep in mind that the drinks could affect you more than they would if you were on land.
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Aviation Health explains how a plane's cabin environment can make alcohol's effect on us more potent:
Alcohol's principal action is to slow down brain activity by restricting oxygen intake to the brain. When passengers ascend to moderate altitudes while on a plane they are already subjected to the additional oxygen deficiency caused by lower pressure in the cabin. This "double-whammy" makes alcohol have a much more powerful effect than normal.
Some air travellers who are more vulnerable than others to the concentration of alcohol in their bloodstream find that the consumption of only a couple of drinks can produce an "instant hangover" that lasts the duration of the flight.
Flying doesn't literally make alcohol more potent or double your blood alcohol levels, as The New York Times has reported, but because being at high altitudes does have a hampering effect, you might not want to order too many drinks in the air.
Arrive in Better Shape [Aviation Health]