Recently, I've noticed something interesting among midsize speakers: many have a very "boomy" quality that grates on the ears. Fortunately, you can fix this boomy bass by adjusting one equaliser frequency.
This isn't a hard and fast rule for every set of speakers out there, but I've found that many -- like the Audioengine A2, or my (otherwise awesome) Yamaha HS50M -- feel a little bloated and boomy in the midbass region. I don't know if this is by design (for the Beats by Dre crowd), unfortunate design, or bad room placement -- or a combination of all three -- but it's incredibly annoying.
If you're having this same problem, here's a very simple fix: turn down the 125hz slider on your equaliser a few dB (whatever sounds good to your ears). This is where I've found most of that "boomy" quality resides. This tweak makes a big difference without making the sound feel "empty", since you're just lowering it enough to get rid of the extra bloat.
Don't confuse this with sub-bass boominess, which can usually be fixed by turning down your subwoofer. This is specifically in the midbass region. Moving your speakers away from the wall may help quite a bit too, but that isn't always practical for a desk setup. This tweak is easy, quick, and it works very well.