Facebook has an awful lot of noise, especially if you're "friends" with people you don't really care about. If you want to clean up your News Feed, Facebook actually has a handy tool to help you do just that.
The tool is somewhat hidden. We still can't really find the button for it on Facebook, but if you head to facebook.com/friends/organize you'll be greeted with a tool designed to pare down your news feed. It finds the friends you haven't interacted with in a while and asks you which ones you want to add to your Acquaintances list where they won't show up as often on your news feed. You can check and uncheck friends as you see fit.
It isn't nearly as effective as creating your own friend lists manually (this tool uses Facebook's smart lists), but it takes just a few minutes and helps Facebook determine what you do and don't see, so it's worth a shot if your News Feed is overflowing with noise.