Getting your resume through the robots is tough enough as it is. While getting the right keywords in is important, an article by the Wall Street Journal also suggests you don't forget to make the file name of your resume fit the job as well.
Chances are your resume's file name is your name, or maybe just "resume". Instead of sending that off to potential employers, change the file name so it's relevant to the position. For example, if you're applying for a project manager position, make the file name "projectmanager". This should help your resume get through the filters and into the hands of a real person. Head over to the Wall Street Journal for a few more tips for getting your resume in order for the digital age.
Tips for Writing a Resume in an Online World [Wall Street Journal]