Whether you have multiple users or just want different setups for work and play, multiple browser profiles are handy. Instead of going through the trouble to set them up, though, reader cbstryker recommends just using Chrome and Chromium side-by-side instead.
Even with apps like previously mentioned ChromeDeck, managing multiple Chrome profiles can be a bit of a pain. If you have two people using the same computer, or you want different setups for yourself, Chromium actually uses an entirely different profile than Chrome does. So, just head to Chromium's snapshot database, download the installer for your platform, and set it up as your second profile. You won't need to create any custom shortcuts, manage any folders, or start any other apps to switch between profiles—just use Chromium for one and Chrome for the other.
It's not the first time we've advocated doing this, but it's useful to know that though extension support has caught up in Chrome, there are still good reasons to keep both browsers around!