Font display technology has made major advances on every platform, but even though the process is highly automated these days, a little tweaking can help. Microsoft's IEBlog runs through the basics for Windows 7 users.
To access the ClearType wizard, just type ClearType into the Windows 7 search box and choose the 'Adjust ClearType text' option, then work through the four screens of examples. It won't necessarily make a major difference depending on your monitor and graphics card, but it's a quick tweak that's worth running through when you set up a machine. We covered a similar strategy back in the seemingly prehistoric XP era, but it's a simpler process in Windows 7.
Sub-pixel fonts in IE9 [IEBlog]