Firefox/Chrome/Opera/Safari (with user script support): The original Helvetireader gave Google Reader a facelift, with a singular font and emphasis on keyboard shortcuts. Helvetireader 2, unofficially released, provides even fewer graphical controls, and the author admits it's not everyone's cup of tea.
Helvetireader's developer has toyed with the idea of releasing Helvetireader 2 as a separate entity, since not everybody might want even more functionality stripped out of Google Reader, with a resulting stronger emphasis on learning all the keyboard shortcuts (visible at any time by entering a "?" key). So before changing everything around, Helvetireader 2 is getting a soft release through Helvetireader's Twitter feed, where you can click to install the mostly finished release as a user script or extension, depending on your browser.
To compare the original Helvetireader with Helvetireader 2, the second release is pictured up top, while this here is the original, both installed in Google Chrome on Windows as an extension:
If getting right to your content and displaying it in a slightly refined manner matters to you, you'll probably dig Helvetireader 2. It's a free download for browsers that support user scripts — Firefox with Greasemonkey installed, Safari with Greasekit, Opera and Chrome.
Helvetireader 2 [@helvetireader]