Linux only: To-Do list application Getting Things GNOME! manages your to-do items easily, complete with tags and nested subtasks.
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The application is available for any variety of Linux with Gnome installed, but Ubuntu users can simply download a .deb file and install it easily. Once you've installed the application you can use the quick add box to start typing in tasks, and then drag and drop to rearrange them into a hierarchy. You'll have to open the to-do item to edit the tags, but if you want to create a task under a tag, just select the tag on the left-hand pane before using the quick add box. It's a simple application, but well worth a look for anybody keeping track of to-do items on their Linux desktop.
Getting Things GNOME! is free and open source, available for Linux only. For more, check out how Tasque manages your to-do list with Remember the Milk integration, or check out the five best to-do list managers.