Speaking as someone who frequently uses the Esc key to close dialogs but still occasionally ends up cursing when hitting the adjacent F1 key launches an unwanted help window, I’m entirely in favour of this concept for notebooks. On a full desktop keyboard, spacing means that keys like Esc are pretty easy to locate, but in a more compact notebook environment, such keys are often the first to get shrunk (or even worse, made accessible only via a Fn-key combination).
While Esc is probably the prime candidate, other keys could also benefit from the same treatment. How would you like to see keyboard layouts altered for better productivity? Share your thoughts in the comments.