Windows only: If you're sporting a wide screen monitor or dual monitors, Edgeless wraps your mouse cursor around one far edge to the other saving you the long haul through the middle.
Edgeless is a simple and portable application. You do have to install it to extract the executable but after that you can just copy it out of the installation directory. As far as input is concerned you simply tell it whether you want it to wrap horizontally, vertically, or both. From then on when you push the mouse cursor against the edges of the monitor Edgeless will jump the cursor to the opposite edge effectively wrapping it around the monitor. Unfortunately Edgeless only works on single and dual monitor setups; for testing we had to disable the third monitor to get it to work. For another multi-monitor friendly application that will cut down on the time you spend mousing about check out Multi-Monitor Mouse. Edgeless is freeware, Windows only.